QBioFusion-QSAR: Quantum Kernel Learning for Small-Data Ligand Classification

QBioFusion-QSAR integrates a quantum fidelity kernel with Morgan/Tanimoto fingerprints to improve ligand classification. On the PsychLight-A benchmark, QMKL increased accuracy and MCC compared to Morgan/Tanimoto alone, with improvements attributed to better predictions of molecules with activity cliffs, such as N-Me-5-HT and N-Me-tryptamine. Auditable analysis confirms localized quantum-kernel contributions in small-data settings.