Talos is an open-source tool that automates iterative reanalysis of genomic data to identify rare disease diagnoses. It achieved a 90% recovery rate of in-scope diagnoses with only 1.3 candidate variants per patient, and delivered 241 new diagnoses across 5,000 undiagnosed patients, with most new findings emerging within 32 days of evidence publication.
Claude Code v2.1.181 introduces support for setting config settings via prompt syntax like /config thinking=false, adds sandbox Apple Events support on macOS, and improves streaming, auto-retry, and subagent behavior. It also fixes numerous bugs related to startup, file handling, clipboard, and UI responsiveness across platforms.
A small-scale experiment shows that native binary embedding models achieve better retrieval than post-hoc binarization of float models. At SciFact Recall@10, native binary models (2048-dim and 4096-dim) outperform post-hoc binary models by 17% and 25% respectively, with significant speed and memory advantages in indexing.
ParallelKernelBench evaluates LLMs on writing fast multi-GPU CUDA kernels for 87 real workloads. The top model generates kernels that perform under a third of the speed of optimal implementations, though a few outputs surpass any existing public code.
The EU AI Act requires all AI systems generating synthetic text to include machine-readable, detectable watermarks using robust, interoperable technical solutions with two layers. This applies to all AI models, including open-source ones, and extends to any service accessible by EU citizens, regardless of location. Non-compliance risks fines of up to 35 million euros or a percentage of annual income, with providers of 'systemic risk' AI models facing heightened liability.
OpenBioRQ introduces a benchmark of 12,553 unsolved biomedical research questions across 12 domains, designed to test agentic models' faithfulness and abstention. It evaluates models in a tool-using setting without answer keys, using real follow-up evidence rather than parametric knowledge, and reveals significant agentic collapse on the hardest questions where tools are no longer used despite being critical.
Latent Personal Memory (LPM) represents user-specific memories as a compact, persistent matrix of N latent slots. These slots are mapped via a shared cross-attention network into dynamic, input-conditioned soft prompts that are prepended to a frozen LLM. LPM outperforms LoRA and Prompt Tuning by up to 8.8% and 54.4% on PersonaMem v1, reduces KV-cache usage by over 64x, matches LoRA accuracy on LoCoMo with 120x fewer parameters, and scales efficiently with context length, outperforming full-context at 128K tokens.
LRE is a CPU-only, language-model-free system that learns which interaction history units are load-bearing. It outperforms baselines in accuracy-cost balance, reducing peak context size by up to 52% and improving task completion by 37% in some cases. LRE achieves superior answer quality with 68% fewer tokens and requires no annotations or neural computation for training.
Beaver is an agent harness that extracts structured information from scientific papers by integrating multimodal evidence tooling, task scaffolding, and artifact-grounded autoresearch. It achieves 81.0 on the Gold-Referenced Attribute Score, outperforming frontier agents by over 23 points, with key gains on high-value attributes requiring cross-modal reasoning.
A new hierarchical attention model detects multi-turn jailbreaks by encoding turns into compact representations and using a lightweight conversation module to capture dialogue dynamics. On 14,038 conversations, it achieves an F1 score of 0.9394, outperforming Claude Opus 4.7 by 0.07 and reducing false-positive rate by half. Ablation studies show that combining cross-attention and self-attention in the conversation module lowers false positives by 2.26 percentage points.
A new study reveals over 1,000 legal filings contain fabricated citations, with the number rising annually. Benchmarking five AI models shows improved performance, with GPT-5 achieving 82.8% recall and 60.5% F1 in agentic settings, though all models struggle with subtle errors and face resource constraints due to limited information access.
NRT-Bench introduces a benchmark for multi-turn red-teaming of LLM agents operating in a simulated nuclear power plant. Across four frontier operator models, 8.7% to 12.1% of attack sessions result in loss of a critical safety function, with vulnerabilities largely disjoint across models. The effectiveness of defences varies significantly by model, showing strong model dependence.
Agentic AI systems face growing threats from model-guided automated attacks. A new defense strategy, Contextual Misdirection via Progressive Engagement (CMPE), reduces attacker success rates by up to two orders of magnitude and nearly eliminates verified attack success in benchmark tests.
Contagion Networks introduces a framework to measure how evaluator biases spread among LLM agents. In a 3-agent experiment, biases propagated consistently with contagion coefficients between 0.157 and 0.352, and homogeneous-model agents showed significantly weaker contagion than cross-model setups. Increasing evaluator committee size from k=1 to k=3 reduced effective contagion by 72.4%.
CWE-Trace evaluates eight vanilla and 15 LoRA-fine-tuned LLMs on Linux kernel vulnerability detection. Results show data contamination offers no advantage, and fine-tuning only shifts output thresholds without altering decision policies. Despite improved detection scores, LLMs lack reliable security reasoning, with top-1 CWE accuracy below 1.3% and binary detection performance at 52.1%.
A new framework enables secure, probabilistic policy enforcement for AI agents in ambiguous environments. It uses distributionally robust optimization to compute rigorous upper bounds on policy violation probabilities without assuming predicate independence. The method outperforms prior approaches on terminal and tool calling agent benchmarks, improving the security-utility trade-off.
This paper introduces Marginal Advantage Accumulation (MAA), a post-processing architecture that addresses cross-batch inconsistency in memory-driven agent self-evolution. MAA formalizes alignment and comparability as structural conditions, uses differential signals and exponential moving average to accumulate signed evidence per operation, and ensures traceability via semantic identity merging. It outperforms batch-level baselines in 14 out of 16 settings and reduces token consumption by about 75%.
A new dataset, IFLLM, collects mouse trajectories and eye gazing data from users interacting with LLMs. It shows that implicit feedback significantly improves LLM alignment, boosting text-based reward model accuracy from 55% to 64% and nearly tripling response quality improvements after DPO training on eight LLMs.
Contagion Networks introduces a framework to measure how evaluator biases spread among LLM agents. In a 3-agent experiment, biases propagate with coefficients between 0.157 and 0.352, and homogeneous-model agents show significantly weaker contagion than cross-model setups. Increasing evaluator committee size from k=1 to k=3 reduces effective contagion by 72.4%.
A new dataset, IFLLM, collects mouse trajectories and eye gazing data from users interacting with LLMs. It shows that implicit feedback significantly improves LLM alignment, boosting text-based reward model accuracy from 55% to 64% and nearly tripling response quality improvements after DPO training on eight LLMs.